The aim of the study was to evaluate the anti inflammatory activity of methanolic extracts of Smithia sensitiva using Carrageenan induced paw edema method. Traditionally Smithia sensitiva is used in inflammation and in cancer. Our study objective is to evaluate scientifically whether it has anti-inflammatory activity. Qualitative chemical analysis of the extract of Smithia sensitiva revealed the presence of alkaloids, glucose and carbohydrates, steroids, tannins and flavanoids. Acute toxicity studies of the extracts showed that a dose up to 800 mg/ Kg body weight on albino mice was non toxic. The extract did not produce any characteristic behavioural changes. The maximum effect was produced at a dose of 400 mg/Kg at 180 minutes of administration and maximum inhibition was to the extent of 64.54%. In carrageenan induced paw edema model the extracts showed a significant anti-inflammatory activity (p<0.001) in a dose dependent manner.
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